Package: gwas2crispr
Type: Package
Title: GWAS-to-CRISPR Data Pipeline for High-Throughput SNP Target
        Extraction
Version: 0.1.5
Authors@R: c(person(given = "Othman S. I.", family = "Mohammed", email = "admin@leopard.ly", role = c("aut", "cre")), person(given = "LEOPARD.LY LTD", role = "cph"))
Description: Provides a reproducible pipeline to conduct genome-wide
        association studies (GWAS) and extract single-nucleotide
        polymorphisms (SNPs) for a human trait or disease. Given
        aggregated GWAS dataset(s) and a user-defined significance
        threshold, the package retrieves significant SNPs from the GWAS
        Catalog using supported trait identifiers, annotates their gene
        context, and can write a harmonised metadata table in
        comma-separated values (CSV) format, genomic intervals in the
        Browser Extensible Data (BED) format, and sequences in the
        FASTA (text-based sequence) format with user-defined flanking
        regions for clustered regularly interspaced short palindromic
        repeats (CRISPR) guide design. The existing efo_id argument is
        retained for backward compatibility. The package prepares
        computational artifacts for downstream workflows; it does not
        perform biological causality testing, clinical interpretation,
        therapeutic design, or wet-lab validation. For details on the
        resources and methods see: Buniello et al. (2019)
        <doi:10.1093/nar/gky1120>; Sollis et al. (2023)
        <doi:10.1093/nar/gkac1010>; Jinek et al. (2012)
        <doi:10.1126/science.1225829>.
License: MIT + file LICENSE
URL: https://github.com/leopard0ly/gwas2crispr
BugReports: https://github.com/leopard0ly/gwas2crispr/issues
Depends: R (>= 4.1)
Imports: httr, dplyr, purrr, tibble, tidyr, readr, stringr, tidyselect
Suggests: Biostrings, BSgenome.Hsapiens.UCSC.hg38, GenomeInfoDb,
        optparse, testthat, knitr, rmarkdown
VignetteBuilder: knitr, rmarkdown
Encoding: UTF-8
Language: en-US
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.3
biocViews: Software, Genetics, VariantAnnotation, SNP, DataImport
Config/pak/sysreqs: libicu-dev libssl-dev libx11-dev
Repository: https://leopard0ly.r-universe.dev
Date/Publication: 2026-06-02 11:51:22 UTC
RemoteUrl: https://github.com/leopard0ly/gwas2crispr
RemoteRef: HEAD
RemoteSha: 9a362057d7cba96729bfdb40188cfe4fd61f8700
NeedsCompilation: no
Packaged: 2026-07-02 09:38:22 UTC; root
Author: Othman S. I. Mohammed [aut, cre],
  LEOPARD.LY LTD [cph]
Maintainer: Othman S. I. Mohammed <admin@leopard.ly>