{ "_id": "6a1efa1db401979e7341850d", "Package": "gwas2crispr", "Type": "Package", "Title": "GWAS-to-CRISPR Data Pipeline for High-Throughput SNP Target\nExtraction", "Version": "0.1.5", "Authors@R": "c(person(given = \"Othman S. I.\", family = \"Mohammed\", email = \"admin@leopard.ly\", role = c(\"aut\", \"cre\")), person(given = \"LEOPARD.LY LTD\", role = \"cph\"))", "Description": "Provides a reproducible pipeline to conduct genome-wide\nassociation studies (GWAS) and extract single-nucleotide\npolymorphisms (SNPs) for a human trait or disease. Given\naggregated GWAS dataset(s) and a user-defined significance\nthreshold, the package retrieves significant SNPs from the GWAS\nCatalog using supported trait identifiers, annotates their gene\ncontext, and can write a harmonised metadata table in\ncomma-separated values (CSV) format, genomic intervals in the\nBrowser Extensible Data (BED) format, and sequences in the\nFASTA (text-based sequence) format with user-defined flanking\nregions for clustered regularly interspaced short palindromic\nrepeats (CRISPR) guide design. The existing efo_id argument is\nretained for backward compatibility. The package prepares\ncomputational artifacts for downstream workflows; it does not\nperform biological causality testing, clinical interpretation,\ntherapeutic design, or wet-lab validation. For details on the\nresources and methods see: Buniello et al. (2019)\n; Sollis et al. (2023)\n; Jinek et al. (2012)\n.", "License": "MIT + file LICENSE", "URL": "https://github.com/leopard0ly/gwas2crispr", "BugReports": "https://github.com/leopard0ly/gwas2crispr/issues", "VignetteBuilder": "knitr, rmarkdown", "Encoding": "UTF-8", "Language": "en-US", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.3", "biocViews": "Software, Genetics, VariantAnnotation, SNP, DataImport", "Config/pak/sysreqs": "libicu-dev libssl-dev libx11-dev", "Repository": "https://leopard0ly.r-universe.dev", "Date/Publication": "2026-06-02 11:51:22 UTC", "RemoteUrl": "https://github.com/leopard0ly/gwas2crispr", "RemoteRef": "HEAD", "RemoteSha": "9a362057d7cba96729bfdb40188cfe4fd61f8700", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-02 15:32:55 UTC", "User": "root" }, "Author": "Othman S. I. Mohammed [aut, cre],\nLEOPARD.LY LTD [cph]", "Maintainer": "Othman S. I. 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